Journal
REPRODUCTIVE TOXICOLOGY
Volume 52, Issue -, Pages 62-70Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.02.004
Keywords
Prenatal exposure; Birth outcomes; KISS1 expression; Endocrine disrupting compounds
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Funding
- National Natural Science Foundation of China [21377077]
- Guangdong University Project for International Cooperation and Innovation Platform [2013gjhz0007]
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In utero co-exposure to endocrine disrupting compounds can perturb fetal development. However, the effect of co-exposure on pivotal regulatory genes has seldom been investigated. We explored the effects of in utero co-exposure to cadmium (Cd), bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on master regulator genes. We recruited 284 healthy pregnant women, of whom 262 provided both cord blood and placenta samples, and 200 had all measurements taken. Placental Cd, cord blood BPA and total PCBs in the exposed group were higher than a reference group. KISS1 expression level in placental tissue was threefold higher in the exposed group than in the reference, and was positively associated with all toxicants. Leptin and leptin receptor expression were also significantly higher, but were only associated with BPA. From our findings, we conclude that lower birth weight is correlated with Cd and PCBs, and may result from the increased KISS1 mRNA expression. (C) 2015 Elsevier Inc. All rights reserved.
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