Journal
MASS SPECTROMETRY REVIEWS
Volume 34, Issue 5, Pages 535-557Publisher
WILEY
DOI: 10.1002/mas.21417
Keywords
microfluidic chip; mass spectrometry; ESI; MALDI
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Funding
- National Basic Research Program of China [2011CB910403]
- National Natural Science Foundation of China [20905027, 30970692, 21075045]
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Microfluidic technology has shown advantages of low sample consumption, reduced analysis time, high throughput, and potential for integration and automation. Coupling microfluidic chips to mass spectrometry (Chip-MS) can greatly improve the overall analytical performance of MS-based approaches and expand their potential applications. In this article, we review the advances of Chip-MS in the past decade, covering innovations in microchip fabrication, microchips coupled to electrospray ionization (ESI)-MS and matrix-assisted laser desorption/ionization (MALDI)-MS. Development of integrated microfluidic systems for automated MS analysis will be further documented, as well as recent applications of Chip-MS in proteomics, metabolomics, cell analysis, and clinical diagnosis. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 535-557, 2015.
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