Journal
MASS SPECTROMETRY REVIEWS
Volume 34, Issue 2, Pages 237-247Publisher
WILEY-BLACKWELL
DOI: 10.1002/mas.21437
Keywords
TOF-SIMS; nanoparticle; biomolecule; mass imaging; surface characterization; signal enhancement
Categories
Funding
- Bio-Signal Analysis Technology Innovation Program of MSIP/NRF [NRF-2006-2005074]
- Converging Research Center for Mass Spectrometric Diagnosis of MSIP/NRF [2013K000429]
- Pioneer Research Program of MSIP/NRF [NRF-2012-0009541]
- Nano Material Technology Development Program of MSIP/NRF [2012M3A7B4035286]
- Global Frontier Project of MSIP/NRF [H-GUARD_2013M3A6B2078962]
- Basic Science Research Programs through MOE/NRF [20120008222, 2012R1A6A1029029]
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Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for label-free drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 237-247, 2015.
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