Journal
MASS SPECTROMETRY REVIEWS
Volume 31, Issue 6, Pages 609-625Publisher
WILEY
DOI: 10.1002/mas.20357
Keywords
isomers; mass spectrometry; ECD; ETD; aspartic acid; leucine
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Funding
- NIH
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Characterization and differentiation of isomers in biological macromolecules using mass spectrometry is one of the most significant challenges facing scientists in the field. The capability of high-resolution MS instruments along with the development of new fragmentation methods now provides the ability to indirectly differentiate between some isomers. This ability has enabled mass spectrometry to evolve into a multidisciplinary technique incorporating areas such as pharmaceutical research, proteomics, polymer science, medicine, environmental chemistry, and recently archeology. This article aims to review recent developments in mass spectrometry methodologies in the identification of structural and spatial isomers in biological macromolecules, such as aspartic acid and isoaspartic acid (Asp/IsoAsp), leucine and isoleucine (Leu/Ile), glutamic acid and ?-glutamic acid, and D/L enantiomers. (c) 2012 Wiley Periodicals, Inc. Mass Spec Rev 31:609625, 2012
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