Journal
MASS SPECTROMETRY REVIEWS
Volume 28, Issue 6, Pages 961-989Publisher
WILEY
DOI: 10.1002/mas.20250
Keywords
mass spectrometry; quadrupole ion trap; tandem mass spectrometry; quadrupole field theory; ion trajectory simulation
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The extraordinary story of the three-dimensional radio-frequency quadrupole ion trap, accompanied by a seemingly unintelligible theoretical treatment, is told in some detail because of the quite considerable degree of commercial success that quadrupole technology has achieved. The quadrupole ion trap, often used in conjunction with a quadrupole mass filter remained a laboratory curiosity until 1979 when, at the American Society for Mass Spectrometry; Conference in Seattle, George Stafford, Jr., of Finnigan Corp., learned of the Masters' study of Allison Armitage of a combined quadrupole ion trap/quadrupole mass filter instrument for the observation of electron impact and chemical ionization mass spectra of simple compounds eluting from a gas chromatograph. Stafford developed subsequently the mass-selective axial instability method for obtaining mass spectra from the quadrupole ion trap alone and, in 1983, Finnigan Corp. announced the first commercial quadrupole ion trap instrument as a detector for a gas chromatograph. In 1987, confinement of ions generated externally to the ion trap was demonstrated and, soon after; the new technique of electrospray ionization was shown to be compatible with the ion trap. (C) 2009 Wiley Periodicals, Inc., Mass Spec Rev 28:961-989, 2009
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