Journal
MARINE POLLUTION BULLETIN
Volume 64, Issue 10, Pages 2160-2167Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2012.07.043
Keywords
Environmental proteomics; High-CO2; Larval proteome; Ocean acidification; Pacific oyster; Veliger
Funding
- HKSAR-RGC [778309M]
- Area of Excellency Project grant [AoE/P-04/2004]
- 973 program
- KAUST-HKUST project
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Most calcifying organisms show depressed metabolic, growth and calcification rates as symptoms to high-CO2 due to ocean acidification (OA) process. Analysis of the global expression pattern of proteins (proteome analysis) represents a powerful tool to examine these physiological symptoms at molecular level, but its applications are inadequate. To address this knowledge gap, 2-DE coupled with mass spectrophotometer was used to compare the global protein expression pattern of oyster larvae exposed to ambient and to high-CO2. Exposure to OA resulted in marked reduction of global protein expression with a decrease or loss of 71 proteins (18% of the expressed proteins in control), indicating a wide-spread depression of metabolic genes expression in larvae reared under OA. This is, to our knowledge, the first proteome analysis that provides insights into the link between physiological suppression and protein down-regulation under OA in oyster larvae. (C) 2012 Elsevier Ltd. All rights reserved.
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