Journal
MARINE DRUGS
Volume 16, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/md16070245
Keywords
deep-sea derived fungus; Phialocephala sp.; nitrogen-containing sorbicillinoids; radical scavenging activity
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Funding
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02, 2016ASKJ08-02]
- Shandong province key research and development program [2016GSF201204]
- Fundamental Research Funds for the Central Universities [201562016]
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Two new nitrogen-containing sorbicillinoids named sorbicillasins A and B (1 and 2) and a new 3,4,6-trisubstituted alpha-pyrone derivative, scirpyrone K (3), together with two known biosynthetically related polyketides (4-5), were isolated from the deep-sea-derived fungus Phialocephala sp. FL30r by using the OSMAC (one strain-many compounds) method. The structures of 1-3, including absolute configurations, were deduced based on MS, NMR, and time-dependent density functional theory (TD-DFT) calculations of specific ECD (electronic circular dichroism) spectra. Compounds 1 and 2 possessed a novel hexahydropyrimido[2,1-a] isoindole moiety, and compound 3 exhibited weak radical scavenging activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) with an IC50 value of 27.9 mu M.
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