Journal
MARINE DRUGS
Volume 16, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md16080278
Keywords
cembranoid-related compounds; flexibilisin; secoflexibilisolide; flexibilisolide; Sinularia flexibilis
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Funding
- Ministry of Science and Technology of Taiwan [MOST104-2113-M-110-006, 105-2113-M-110-002]
- National Sun Yat-sen University-Kaohsiung Medical University (NSYSU-KMU) Joint Research Projects [NSYSUKMU 105-I008, 106-I007]
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Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6-14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
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