Journal
MARINE DRUGS
Volume 16, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/md16090307
Keywords
alpha-glucosidase inhibitors; mangrove endophytic fungus; Aspergillus flavus
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Funding
- key project of Natural Science Foundation of Guangdong Province [2016A040403091] Funding Source: Medline
- National Natural Science Foundation of China [81741162, 2187713, 21472251] Funding Source: Medline
- Special Promotion Program for Guangdong Provincial Ocean and Fishery Technology [A201701C06] Funding Source: Medline
- GDME [2018C004] Funding Source: Medline
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Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3-6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1-6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their -glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5-4.5 M.
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