Journal
MARINE DRUGS
Volume 16, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/md16090335
Keywords
mangrove-derived fungus; Aspergillus versicolor; tetrahydroxanthone dimers; antibacterial activity; cytotoxicity
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Funding
- Fundamental Research Funds for the Central Universities [201562016] Funding Source: Medline
- Scientific and Technological Innovation Project for Marine Science and Technology supported by Qingdao National Laboratory [2016ASKJ08-02] Funding Source: Medline
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403] Funding Source: Medline
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02 and 2016ASKJ08-02] Funding Source: Medline
- Shandong province key research and development program [2016GSF201204] Funding Source: Medline
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Three new tetrahydroxanthone dimers, 5-epi-asperdichrome (1), versixanthones N (2), and O (3), were isolated from the mangrove-derived fungus Aspergillus versicolor HDN1009. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and circular dichroism (CD) experiments. Among them, compound 1 was the second example of tetrahydroxanthone dimers, which dimerized by a rare diaryl ether linkage and showed promising antibacterial activities against Vibrio parahemolyticus, Bacillus subtilis, Mycobacterium phlei, and Pseudomonas aeruginosa, with MIC values ranging from 100 M to 200 M; whilst compounds 2 and 3 exhibited extensive cytotoxicities against five cancer cell lines (HL-60, K562, H1975, MGC803, and HO-8910), with IC50 values ranging from 1.7 M to 16.1 M.
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