Journal
MARINE DRUGS
Volume 12, Issue 12, Pages 5902-5915Publisher
MDPI AG
DOI: 10.3390/md12125902
Keywords
Engyodontium album; polyketides; spectroscopic data; cytotoxicity; antilarval
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Funding
- National Marine Public Welfare Research Project of China [201305017]
- Natural Science Foundation of China [41376160]
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]
- Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]
- Science and Technology Planning Project of Guangdong Province [2013B031100001]
- Marine Fishery Science and Technology Promotion Project of Guangdong Province [A201301B05]
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Eight new chromones, engyodontiumones A-H (1-8), and three new phenol derivatives (9-11) together with eight known polyketides (12-19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 mu M, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.
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