Journal
MARINE DRUGS
Volume 12, Issue 2, Pages 1013-1022Publisher
MDPI
DOI: 10.3390/md12021013
Keywords
Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus
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Funding
- University of Wisconsin-Madison School of Pharmacy
- Graduate School at the University of Wisconsin
- UW College of Agriculture and Life Sciences
- NIH, NIGMS [R01 GM092009]
- NSF [CHE-9304546, DMB-8415048, OIA-9977486, BIR-9214394]
- NIH [P41RR02301, P41GM66326, RR02781, RR08438]
- University of Wisconsin
- USDA
- [R01 GM104192]
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Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-C-13 glucose, and analysis of a C-13-C-13 COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
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