Journal
MARINE DRUGS
Volume 12, Issue 4, Pages 2156-2163Publisher
MDPI AG
DOI: 10.3390/md12042156
Keywords
deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity
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Funding
- National Natural Science Foundation of China [81102333, 81273400]
- Fujian Natural Science Foundation for Distinguished Young Scholars [2012J06020]
- R&D Special Fund for Public Welfare Industry (Oceanography) [201005022-1, 201005032-1]
- China Ocean Mineral Resources RD Association [COMRA DY125-15-T-07]
- Xiamen South Marine Center project [13GZP002NF08]
- Fundamental Research Funds for the Central Universities [2010121108]
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Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.
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