Journal
MARINE DRUGS
Volume 12, Issue 10, Pages 5124-5131Publisher
MDPI AG
DOI: 10.3390/md12105124
Keywords
gut fungi; Aspergillus sp.; aspochalasin; methylthiol; cytotoxicity
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Funding
- National Natural Science Foundation of China (NSFC) [21102128]
- Qianjiang Excellence Project of Zhejiang Province [2010R10053]
- Union Opening Foundation of the CAS Key Laboratory of Marine-Resources Sustainable Utilization, Chinese Academy of Sciences [LMB121004]
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Two novel aspochalasins, 20-beta-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 mu M, respectively.
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