Journal
MARINE DRUGS
Volume 12, Issue 8, Pages 4677-4692Publisher
MDPI AG
DOI: 10.3390/md12084677
Keywords
Briareum violacea; briarane diterpenoids; briaviolides; anti-inflammatory activities
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Funding
- National Science Council, Taiwan [NSC 98-2113-M-002-002-MY2]
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Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4 beta-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (H-1- and C-13-NMR, H-1-H-1 COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/Cytochalasin B (fMLP/CB).
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