Journal
MARINE DRUGS
Volume 12, Issue 2, Pages 589-600Publisher
MDPI AG
DOI: 10.3390/md12020589
Keywords
Junceella gemmacea; briarane; diterpenoid; junceellolide
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Funding
- Natural Science Foundation of China [81172979]
- National Marine 863 Project [2013AA092902]
- International Science and Technology Cooperation Program of China [0S2014GR0014]
- Hundred Talents Program of Shanghai Municipal Commission of Health [XBR2013111]
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Four new briarane diterpenoids, junceellolides M-P (1-4), were isolated together with seven known analogs (5-11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1-3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
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