Journal
MARINE DRUGS
Volume 12, Issue 6, Pages 3371-3380Publisher
MDPI AG
DOI: 10.3390/md12063371
Keywords
soft coral; Sinularia numerosa; numerosol A-D; gibberoketosterol; cytotoxicity
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Funding
- National Science Council [NSC102-2320-B-110-003-MY3]
- NSYSUKMU Joint Project [NSYSUKMU 103-P016]
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Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 mu M.
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