Journal
MARINE DRUGS
Volume 12, Issue 4, Pages 2019-2035Publisher
MDPI
DOI: 10.3390/md12042019
Keywords
human papillomavirus; cervical cancer; pathogenesis; heparinoid polysaccharide; entry process; apoptosis
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Funding
- National Natural Science Foundation of China [81302811]
- Shandong Provincial Natural Science Foundation [ZR2011HQ012]
- Special Fund for Marine Scientific Research in the Public Interest [201005024]
- Qingdao science and technology development project [12-1-4-1-(20)-jch]
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Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of anti-HPV and related cancer activities. This paper will review the recent progress in research on the potential anti-HPV and related cancer agents from marine resources. In particular, it will provide an update on the anti-HPV actions of heparinoid polysaccharides and bioactive compounds present in marine organisms, as well as the therapeutic vaccines relating to marine organisms. In addition, the possible mechanisms of anti-HPV actions of marine bioactive compounds and their potential for therapeutic application will also be summarized in detail.
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