Journal
MARINE DRUGS
Volume 12, Issue 12, Pages 6102-6112Publisher
MDPI AG
DOI: 10.3390/md12126102
Keywords
marine-derived actinomycete; Streptomyces sp.; streptcytosines A-E; anti-mycobacterium activity; amicetin
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [25870660]
- Foundation for Japanese Chemical Research
- Grants-in-Aid for Scientific Research [25870660] Funding Source: KAKEN
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Five new nucleoside antibiotics, named streptcytosines A-E (1-5), and six known compounds, de-amosaminyl-cytosamine (6), plicacetin (7), bamicetin (8), amicetin (9), collismycin B (10), and SF2738 C (11), were isolated from a culture broth of Streptomyces sp. TPU1236A collected in Okinawa, Japan. The structures of new compounds were elucidated on the basis of their spectroscopic data (HRFABMS, IR, UV, and 2D NMR experiments including H-1-H-1 COSY, HMQC, HMBC, and NOESY spectra). Streptcytosine A (1) belonged to the amicetin group antibiotics, and streptcytosines B-E (2-5) were derivatives of de-amosaminyl-cytosamine (6), 2,3,6-trideoxyglucopyranosyl cytosine. Compound 1 inhibited the growth of Mycobacterium smegmatis (MIC = 32 mu g/mL), while compounds 2-5 were not active at 50 mu g/disc. Bamicetin (8) and amicetin (9) showed the MICs of 16 and 8 mu g/mL, respectively.
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