Journal
MARINE DRUGS
Volume 12, Issue 6, Pages 3283-3291Publisher
MDPI AG
DOI: 10.3390/md12063283
Keywords
Streptomyces sp.; violapyrones; anti-cancer activity; alpha-pyrones; starfish
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Funding
- Korea Institute of Ocean Science and Technology [PE99273]
- Ministry of Oceans and Fisheries, Korea [PM57561]
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Two new alpha-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI(50) values of 1.10-26.12 mu g/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
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