Journal
MARINE DRUGS
Volume 12, Issue 9, Pages 4799-4809Publisher
MDPI
DOI: 10.3390/md12094799
Keywords
metagenome; siderophore; avaroferrin; biosynthesis; heterologous expression
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Funding
- JST Special Coordination Funds for Promoting Science and Technology
- JSPS [25108701]
- Grants-in-Aid for Scientific Research [25108701] Funding Source: KAKEN
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The siderophore avaroferrin (1), an inhibitor of Vibrio swarming that was recently identified in Shewanella algae B516, was produced by heterologous expression of the biosynthetic gene cluster cloned from a deep-sea sediment metagenomic DNA, together with two analogues, bisucaberin (2) and putrebactin (3). Avaroferrin (1) is a macrocyclic heterodimer of N-hydroxy-N-succinyl cadaverine (4) and N-hydroxy-N-succinyl-putrescine (5), whereas analogues 2 and 3 are homodimers of 4 and 5, respectively. Heterologous expression of two other related genes from culturable marine bacteria resulted in production of compounds 1-3, but in quite different proportions compared with production through expression of the metagenomic DNA.
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