Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 2937-2952Publisher
MDPI AG
DOI: 10.3390/md12052937
Keywords
Haliclona simulans; marine sponges; steroids; antitrypanosomal; anti-mycobacterial
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Funding
- Scottish Overseas Research Students Award Scheme (SORSAS)
- Beaufort Marine Biodiscovery Research award - Irish Government under the National Development Plan
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The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3 beta,24-diol and 20-methyl-pregn-6-en-3 beta-ol, 5 alpha,8 alpha-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact-and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.
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