Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 2748-2759Publisher
MDPI
DOI: 10.3390/md12052748
Keywords
lyngbyatoxin A; cyanobacteria; Moorea producens; toxicity; protein kinase C
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Funding
- JSPS [24510294]
- Grants-in-Aid for Scientific Research [24510294] Funding Source: KAKEN
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Lyngbyatoxin A from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) is known as the causative agent of. swimmer's itch. with its highly inflammatory effect. A new toxic compound was isolated along with lyngbyatoxin A from an ethyl acetate extract of M. producens collected from Hawaii. Analyses of HR-ESI-MS and NMR spectroscopies revealed the isolated compound had the same planar structure with that of lyngbyatoxin A. The results of optical rotation and CD spectra indicated that the compound was a new lyngbyatoxin A derivative, 12-epi-lyngbyatoxin A (1). While 12-epi-lyngbyatoxin A showed comparable toxicities with lyngbyatoxin A in cytotoxicity and crustacean lethality tests, it showed more than 100 times lower affinity for protein kinase C delta (PKC delta) using the PKC delta-C1B peptide when compared to lyngbyatoxin A.
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