Nocapyrones: α-and γ-Pyrones from a Marine-Derived Nocardiopsis sp.

One new alpha-pyrone (nocapyrone R (1)), and three known gamma-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. gamma-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the alpha-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.