Journal
MARINE DRUGS
Volume 12, Issue 12, Pages 6178-6189Publisher
MDPI AG
DOI: 10.3390/md12126178
Keywords
structure elucidation; briarane diterpenoids; tumor cell growth inhibitory activity; gorgonian; Dichotella gemmacea
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Funding
- Natural Science Foundation of China [81172979, U1405227]
- National Marine 863 Project [2013AA092902]
- International Science and Technology Cooperation Program of China [2014DFG32640]
- Hundred Talents Program of Shanghai Municipal Commission of Health [XBR2013111]
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Seven new briarane diterpenoids, gemmacolides AS-AY (1-7), were isolated together with ten known analogues (8-17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells.
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