Journal
MARINE DRUGS
Volume 12, Issue 12, Pages 6028-6037Publisher
MDPI AG
DOI: 10.3390/md12126028
Keywords
Lobophytum crassum; seco-cembranoid; Mosher's acylation; antiviral activity
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Funding
- National Science Council of Taiwan [NSC102-2320-B-110-003-MY3, NSC102-2113-M-390-001]
- NSYSUKMU Joint Project [NSYSUKMU 103-P016]
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Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 mu g/mL.
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