Journal
MARINE DRUGS
Volume 12, Issue 12, Pages 5930-5943Publisher
MDPI
DOI: 10.3390/md12125930
Keywords
marine fungi; Penicillium thomii; Penicillium lividum; 6,6-spiroketals
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Funding
- Russian Foundation for Basic Research [RFBR N 14-04-00910-a, 14-03-31318-mol-a]
- Russian Federation [MK-6019.2014.4]
- Far Eastern Federal University [14-08-01-34_u]
- Russian Science Foundation [14-14-00030]
- Russian Science Foundation [14-14-00030] Funding Source: Russian Science Foundation
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Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 mu M.
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