Journal
MARINE DRUGS
Volume 12, Issue 10, Pages 5316-5327Publisher
MDPI AG
DOI: 10.3390/md12105316
Keywords
soft coral; Sinularia sp.; sinulolide; NF-kappa B
Categories
Funding
- National Key Basic Research Program of China [2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [21302198, 31270402, 21172230, 30973679, 41176148, 21002110]
- Chinese Academy of Sciences [XDA11030403, SQ201117, SQ201019]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001]
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Eight new compounds, sinulolides A-H (1-8), along with two known compounds, alpha-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-kappa B activation.
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