Journal
MARINE DRUGS
Volume 12, Issue 7, Pages 4086-4095Publisher
MDPI
DOI: 10.3390/md12074086
Keywords
deferoxamine; enterovirus 71; hand; foot and mouth disease; B cells
Categories
Funding
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2012BA139B02]
- National Science and Technology Major Projects of Infectious Disease of China [2012ZX10004501]
- Youth Foundation of CAMS PUMC [3332013041]
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Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.
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