Journal
MARINE DRUGS
Volume 12, Issue 7, Pages 3904-3916Publisher
MDPI AG
DOI: 10.3390/md12073904
Keywords
sponge-associated fungus; Hansfordia sinuosae; punctaporonins H-M; structural elucidation; lowering lipid accumulation
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Funding
- COMRA [DY125-15-T-01]
- SOA [201031912 3366025-4]
- NSFC [30930109]
- National Hi-Tech 863-Projects [2011AA090701, 2013AA092902, 2013AA093003]
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Six new caryophyllene-based sesquiterpenoids named punctaporonins H-M (1-6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H-I (1-2). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels.
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