Journal
MARINE DRUGS
Volume 12, Issue 7, Pages 3982-3993Publisher
MDPI AG
DOI: 10.3390/md12073982
Keywords
sponge; Hyrtios erecta; Thorectidae; hainanerectamines; indole; beta-carboline; Aurora A
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Funding
- National Marine 863 Projects [2011AA09070102, SS2013AA090202]
- Natural Science Foundation of China [41306130, 21072204, 81273430, 20721003]
- State Key Laboratory of Drug Research-SIMM [SIMM1203KF-12]
- China Postdotoral Science Foundation [2012M520956]
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Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new beta-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5-8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2-4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC50 values of 24.5, 13.6, and 18.6 mu g/mL, respectively.
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