Journal
MARINE DRUGS
Volume 12, Issue 3, Pages 1271-1280Publisher
MDPI AG
DOI: 10.3390/md12031271
Keywords
spirobisnaphthalene; Rhytidhysteron sp.; endophytic fungus; cytotoxicity
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Funding
- Thailand Research Fund [RSA5580023]
- Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University [RES560530208-AS]
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Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
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