Journal
MARINE DRUGS
Volume 12, Issue 4, Pages 1699-1714Publisher
MDPI AG
DOI: 10.3390/md12041699
Keywords
marine natural product; phenazine; Baltic Sea; Streptomyces; Halichondria panicea; HPLC-DAD; MS; fermentation; PDE 4; antibiotic
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Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.
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