4.7 Article

Discovery of Novel Diterpenoids from Sinularia arborea

Journal

MARINE DRUGS
Volume 12, Issue 1, Pages 385-393

Publisher

MDPI AG
DOI: 10.3390/md12010385

Keywords

sinularbol; sinularborane; diterpenoid; Sinularia arborea; superoxide anion

Funding

  1. National Dong Hwa University
  2. Chang Gung Memorial Hospital [CMRPG3C0141]
  3. National Museum of Marine Biology and Aquarium
  4. Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University
  5. National Science Council, Taiwan [NSC 102-2325-B-291-001, 101-2320-B-291-001-MY3]

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Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils.

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