Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 3060-3071Publisher
MDPI
DOI: 10.3390/md12053060
Keywords
soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity
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Funding
- National Science Council of Taiwan [NSC 102-2113-M-110-001-MY2]
- Aim for the Top University Program from Ministry of Education of Taiwan [02C030205]
- National Sun Yat-sen University-Kaohsiung Medical University Joint Project [NSYSU-KMU 02C030117]
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Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.
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