Journal
MARINE DRUGS
Volume 12, Issue 2, Pages 746-756Publisher
MDPI
DOI: 10.3390/md12020746
Keywords
marine sediment; Penicillium brefeldianum SD-273; indolediketopiperazine; brine shrimp lethality
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Funding
- Ministry of Science and Technology of China [2013AA092901, 2012AA092104]
- Natural Science Foundation of China [31270403]
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Three new indolediketopiperazine peroxides, namely, 24-hydroxyverruculogen (1), 26-hydroxyverruculogen (2), and 13-O-prenyl-26-hydroxyverruculogen (3), along with four known homologues (4-7), were isolated and identified from the culture extract of the marine sediment-derived fungus Penicillium brefeldianum SD-273. Their structures were determined based on the extensive spectroscopic analysis and compound 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of compounds 1-3 was determined using chiral HPLC analysis of their acidic hydrolysates. Each of the isolated compounds was evaluated for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
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