Journal
MARINE DRUGS
Volume 12, Issue 2, Pages 672-681Publisher
MDPI AG
DOI: 10.3390/md12020672
Keywords
gorgonian; Echinogorgia pseudossapo; tetraprenylated alkaloids; phosphodiesterases
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Funding
- National Natural Science Foundation of China [81102339]
- Key Laboratory of East China Sea & Oceanic Fishery Resources Exploitation and Utilization, Ministry of Agriculture, China [K201203]
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Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 mu M, respectively.
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