Journal
MARINE DRUGS
Volume 12, Issue 4, Pages 2326-2340Publisher
MDPI
DOI: 10.3390/md12042326
Keywords
sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT and Future Planning) [M1A5A1-2010-0020429]
Ask authors/readers for more resources
Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 1-3 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayed significant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancer cell line HCT116.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available