Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 2816-2826Publisher
MDPI AG
DOI: 10.3390/md12052816
Keywords
marine fungus; bryozoan; Beauveria felina; secondary metabolites; bioactivity
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Funding
- National Natural Science Foundation of China [31270403]
- Ministry of Science and Technology [2013AA092901, 2010CB833802]
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Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4-7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
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