Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 2760-2770Publisher
MDPI
DOI: 10.3390/md12052760
Keywords
Suberites waedoensis; cyclic cystine bridged peptides; chujamides; cytotoxicity; Na+/K+-ATPase
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Funding
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT and Future Planning) [2010-0020429, 2009-0083533]
- National Research Foundation of Korea [2010-0020429] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca-and undecapeptides. The absolute configurations of all amino acid residues were determined to be L by advanced Marfey's analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na+/K+-ATPase.
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