Journal
MARINE DRUGS
Volume 12, Issue 5, Pages 2446-2457Publisher
MDPI AG
DOI: 10.3390/md12052446
Keywords
soft coral; Cladiella hirsuta; eunicellins: cytotoxic activity; anti-inflammatory activity
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Funding
- National Science Council [100-2320-B-110-001-MY2]
- NSYSU-KMU JOINT RESEARCH PROJECT (NSYSUKMU) [02C030117]
- Aim for the Top University Program from Ministry of Education of Taiwan [02C030205]
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New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
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