Journal
MARINE DRUGS
Volume 12, Issue 4, Pages 2144-2155Publisher
MDPI AG
DOI: 10.3390/md12042144
Keywords
eunicellin; Cladiella; cladieunicellin; cytotoxicity
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Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- National Science Council, Taiwan [NSC 102-2325-B-291-001, 101-2320-B-291-001-MY3]
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Five new 7-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M-Q (1-5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1-5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1-5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 M, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
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