Journal
MARINE DRUGS
Volume 11, Issue 12, Pages 4741-4750Publisher
MDPI AG
DOI: 10.3390/md11124741
Keywords
soft coral; Sinularia sp; sesquiterpenes; sinularianins; NF-B
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Funding
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- National High Technology Research and Development Program (863 Program) [2012AA092104]
- National Natural Science Foundation of China [21302198, 31270402, 21172230, 30973679, 41376162, 41176148]
- Knowledge Innovation Program of Chinese Academy of Science [SQ201117, SQ201019]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
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Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-B activation using the cell-based HEK293 NF-B luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 mu g/mL, respectively.
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