Journal
MARINE DRUGS
Volume 11, Issue 5, Pages 1693-1717Publisher
MDPI
DOI: 10.3390/md11051693
Keywords
natural products; peptides; polyketides; therapeutic agents
Categories
Funding
- PharmaMar (Madrid), CICYT [CTQ2012-30930]
- Generalitat de Catalunya [2009SGR 1024]
- Institute for Research in Biomedicine (IRB Barcelona)
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Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as head-to-side-chain cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a beta-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
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