Journal
MARINE DRUGS
Volume 11, Issue 12, Pages 4788-4798Publisher
MDPI
DOI: 10.3390/md11124788
Keywords
soft coral; Sarcophyton sp; polyhydroxylated steroids; cytotoxicities; anti-H1N1 activity
Categories
Funding
- National Natural Science Foundation of China [41076084, 21102136]
- Hi-tech Research and Development Program of China [2013AA092902, 2013AA093002]
Ask authors/readers for more resources
Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed the 3,5,6-trihydroxylated steroidal nucleus. The cytotoxicities against selected HL-60, HeLa and K562 tumor cell lines and anti-H1N1 (Influenza A virus (IAV)) activities for the isolates were evaluated. Compounds 2, 3 and 5-8 exhibited potent activities against K562 cell lines with IC50 values ranging from 6.4 to 10.3 M. Compounds 1, 6-8 potently inhibited the growth of HL-60 tumor cell lines, and 6 also showed cytotoxicity towards HeLa cell lines. In addition, preliminary structure-activity relationships for the isolates are discussed. The OAc group at C-11 is proposed to be an important pharmacophore for their cytotoxicities in the 3,5,6-triol steroids. Compounds 4 and 9 exhibited significant anti-H1N1 IAV activity with IC50 values of 19.6 and 36.7 g/mL, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available