Journal
MARINE DRUGS
Volume 11, Issue 11, Pages 4585-4593Publisher
MDPI AG
DOI: 10.3390/md11114585
Keywords
eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity
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Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- National Science Council, Taiwan [NSC 102-2325-B-291-001, 101-2320-B-291-001-MY3]
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A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.
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