Journal
MARINE DRUGS
Volume 11, Issue 4, Pages 1162-1172Publisher
MDPI
DOI: 10.3390/md11041162
Keywords
soft coral; Lobophytum; cembranoids; cytotoxicity; antibacterial activity
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Funding
- NSFC [21202123]
- Start-Up Funding from Wenzhou Medical College [QTJ10018]
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Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new alpha-methylene-gamma-lactone-containing cembranoids, (1R*,3R*,4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E,11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*, 7S*, 14S*, 3E, 11E)-18-acetoxy-7-hydroperoxycembra-3,8(19), 11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4-14. The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1-3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae.
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