Journal
MARINE DRUGS
Volume 11, Issue 1, Pages 136-145Publisher
MDPI AG
DOI: 10.3390/md11010136
Keywords
Paraminabea acronocephala; paraminabic acid; soft coral; cytotoxicity; anti-inflammatory activity
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Funding
- National Science Council of Taiwan [NSC100-2320-B-110-001-MY2]
- Ministry of Education [00C030205]
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Three new steroidal carboxylic acids, paraminabic acids A-C (1-3) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC50 values ranging from 2.05 to 2.83 mu g/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
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