Journal
MARINE DRUGS
Volume 11, Issue 8, Pages 3068-3076Publisher
MDPI
DOI: 10.3390/md11083068
Keywords
marine fungus; sediment; anthranilic acid; Penicillium paneum; cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [30901880]
- Ministry of Science and Technology of China [2012AA092104, 2013AA092901]
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Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
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