Journal
MARINE DRUGS
Volume 11, Issue 2, Pages 387-398Publisher
MDPI AG
DOI: 10.3390/md11020387
Keywords
marine-derived bacteria; Kocuria palustris; thiazolyl peptides; structure elucidation; antibacterial activity
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Funding
- Ministerio de Ciencia e Innovacion [PCT-010000-2010-4, INP-2011-0016-PCT-010000-ACT6]
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A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey's analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
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